The A438 at Bridge Sollars, west of Hereford, is closed both ways after a crash.
Emergency services are at the scene between the Bishopstone turn off (Bridge Sollers Crossroads, Bridge Sollers) and the B4230 (Mansell Gamage).
Traffic between Hereford and Staunton-on-Wye is being badly disrupted.
The accident involved a van and motorcycle, and emergency services are at the scene.
5.45pm update: The road has reopened.
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